Catálogo general VIH/sida
A clinical utility evaluation of dual HIV/syphilis point-of-care tests in non-clinical settings for screening for HIV and syphilis in men who have sex with men
Resumen
Background Dual point-of-care tests (POCTs) for the simultaneous detection of antibodies to HIV and syphilis have been developed. Since community-based organisations (CBO) are effective providers of HIV and syphilis test- ing among men who have sex with men (MSM), evaluation of the utility of these dual tests at CBO testing services is a high priority. The aim of this study is to determine the feasibility of performing dual HIV-syphilis POCT testing among both users and providers at these non-clinical sites. Methods This evaluation assessed the utility of two lateral flow immunochromatographic antibody technologies for dual screening for HIV/syphilis among MSM seeking testing in four CBO testing services in Spain, Slovenia, Latvia, and Ukraine. The study’s conceptual framework divides the concept of feasibility into two inter-related domains, acceptability, and usability and further breaks it down into six subdomains: learnability, willingness, suitability, satisfac- tion, efficacy, and effectiveness. The feasibility analysis was performed by calculating the median score in 3 stages (for individual questions, subdomains, and domains), using a summated scores method. Results The final sample included 844 participants, 60 of which were found to be HIV test positive (7.1%) and 61 (7.2%) positive on testing for syphilis. There was a small difference (1.1%) when comparing the results of the two dual POCTs under evaluation to the tests routinely used at each site. The inter-rater agreement showed a high concord- ance between two independent readings. The analysis of the feasibility for the users of the services indicated good satisfaction, suitability, and willingness. In addition, among 18 providers the total mean score showed good accept- ability and usability, good willingness, easy learnability, high suitability, and good efficacy, but lower satisfaction and effectiveness. The operational characteristics of both dual study POCTs were well evaluated by providers. Conclusions The introduction of dual HIV and syphilis POCTs in CBO testing services for screening of MSM is fea- sible, with a high acceptability and usability both for users and providers. Implementation of dual POCTs for HIV and syphilis in CBO testing services is an opportunity for scaling up integrated HIV/syphilis testing for MSM
Autoría:
FERNÁNDEZ LÓPEZ, Laura; REYES URUEÑA, Juliana; EGEA CORTÉS, Laia; CHERNYSHEV, Andrii; UPMACE, Inga; COSIC, Mitja; MEJÍAS NAVARRO, William; BLONDEEL, Karel; SOE THWIN, Soe; GIOS, Lorenzo; MIRANDOLA, Massimo; PEELING, Rosanna; KIARIE, James; CASABONA BARBARÀ, Jordi; TOSKIN, Igor
Autoría institucional: ProSPeRo group
Autoría institucional: ProSPeRo group
Ficha bibliográfica
- Año de publicación:
- 2024
- Publicación:
- [S.l.] : BioMed Central
- En :
- Número:
- Vol. 24:264 (2024), 15 p.
- Formato:
- Artículo
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