Catálogo general VIH/sida
Clinical outcomes among HIV-infected Africans with advanced disease in Spain
Resumen
Objectives: To characterize advanced HIV disease (AHD) among African people living with HIV (PLHIV), and to compare its prevalence, clinical-epidemiological characteristics, and outcomes between Africans and individuals from other regions (OtR) living in Spain. Methods: Prospective cohort study among all adult PLHIV enrolled in Spanish AIDS Research Network Cohort, a multicenter cohort of antiretroviral therapy-naïve PLHIV enrolled in 45 Spanish centers between 2004and 2017. AHD was defined as having CD4 cell count < 200 cells/mm3 at diagnosis; loss to follow-up (LTFU) as not having a visit >365 days since last follow-up visit; and attrition, as death / LTFU. This study is part of an international multi-cohort collaboration to characterize AHD among African PLHIV. Results: Overall, 13.851 subjects were analysed, including 635 (4.6%) African individuals. Compared with PLHIV from Western Europe (WE), Africans were predominantly women (55% vs. 12.1%, p< 0.001), had lower median CD4 count (299 [155-477] vs 408 [223-609], p< 0.001) and higher proportion of AIDS-defining illnesses (19.4% vs. 10.9%, p< 0.001) at HIV diagnosis. 31% of Africans presented with AHD vs. 22.4% WE and 24.5% OtR (P< 0.001). Median follow-up was 42 [15-88], 60 [22-105] and 47 [14-91] months among Africans, WE and OtR respectively. Of those with AHD, 12.2% Africans vs 33.2% WE developed non-AIDS comorbidities during follow-up. Among Africans, 42% were kidney-related (8/10, acute renal failure). 44.2% of Africans were LTFU compared with 17.3%, 30.1% ,WE and OtR respectively. Mortality was documented in 6.6% Africans vs 12.2% WE. Causes of death were similar by region of origin and mainly HIV/AIDS-related. Conclusion: AHD is a major concern among African PLHIV in Spain. The high proportion of attrition and the occurrence of renal comorbidities during follow-up are of particular relevance. The lower mortality observed among Africans is likely biased by the higher rates of LTFU in this group.- Tema:
Autoría:
RAMÍREZ MÉNDEZ, Ana; JAEN, Àngels; ALEJOS FERRERAS, Belén; JARRÍN VERA, Inmaculada; MORENO, Santiago; WANDELER, G.; DALMAU JUANOLA, David; LETANG, E.
Autoría institucional: REIS (Red Española de Investigación en Sida) (España)
Autoría institucional: REIS (Red Española de Investigación en Sida) (España)
Ficha bibliográfica
- Año de publicación:
- 2019
- Descripción física:
- [1] p.
- Formato:
- Folleto
- Tipo de documento:
- Coloquios y ponencias
- Notas:
- Póster presentado en la 17th European AIDS Conference, celebrada del 6 al 9 de noviembre de 2019 en Basilea (Suiza).
- Más información:
-
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